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KMID : 0372919970180030301
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Journal of Biomedical Engineering Research
1997 Volume.18 No. 3 p.301 ~ p.306
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Quantitative Evaluation of the Remaining Hepatic Function after Surgery in Patients with Hepatic Cancer using Deconvolution Technique of Tc-99m DISIDA SCAN
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Kim Deok-Won
Kim Su-Chan
Yun Seok-Jin
Lee Jong-Du
Kim Byong-Ro
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Abstract
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Surgical removal of hepatic cancerous tissues have been widely performed due to its early detection. However, a patient can not survive if excessive hepatic tissues were removed. Therefore, quantitative evaluation of remaining hepatic function after surgery is a really important factor for surgeon. the currently used ICG Rmax and Lidocaine clearance tests have disadvantages such as tedium, complexity, and inability to estimate remaining hepatic function after surgery. While HEF has advantages such as simplicity, quickness, nonivasiveness, and quantification, its reliability has been doubtful. Thus, the program for calculation of HEF has been developed from serial gamma camera image data. And we compared the reliability of HEF with ICG Rmax and Lidocaine clearance test using 6normal and 18 abnormal rabbits with damaged livers. The correlation coefficient of HEF to ICG Rmax and MEGX was 0.91, 0.94, respectively. I was also found that the HEFs of normal and abnormal hepatic tissues was higher than 100% and lower than 80%, respectively. Thus we confirmed that HEF can be a good indicator distinguishing between abnormal tissues and normal ones. Finally, we could conclude that patients would survive if both the pre-and the post-operative HEF were greater than 60%.
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KEYWORD
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Hepatic Extraction Fraction, ICG Rmax, Lidocaine Clearance Test, Deconvolution
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